On June 9, 2010 Portland Pie opened its fourth location in Manchester, New Hampshire.  The new pizzeria is near the intersection of Merrimack Street, adjacent to Veterans Memorial Park.

The 4100 square-foot restaurant has 25 tables, as well as a 15-seat, fully stocked bar, complete with high definition televisions. Like the other Portland Pie locations in Portland, Westbrook and Scarborough, it features a large fireplace and walls that are festooned with a great deal of old-time New England memorabilia.